Sentence examples for both wildtype and mutant from inspiring English sources

We observed sustained reduction of both wildtype and mutant ataxin-7 as well as a significant improvement of ataxia phenotypes.

Here, we designed RNAi sequences to reduce the expression of both wildtype and mutant ataxin-7 to test if reducing ataxin-7 in Purkinje cells is both tolerated and beneficial in an animal model of SCA7.

These data demonstrate that reduction of both wildtype and mutant ataxin-7 by RNAi is well tolerated, and contrary to what may be expected from reducing a component of the Spt-Taf9-Gcn5 acomplexansferase complex, is efficacious in the SCA7 mouse.

We therefore decided to establish the detailed dynamics of methylation at all known regulatory elements of the gene using both wildtype and mutant ES cell lines.

We performed ChIP analyses on both wildtype and mutant MYC alleles [wt, ΔLg, ΔCTCF-N, and ΔCTCF-NA] residing in murine B78 cells (Figure 3).

(B ) Functional combinations of the neuron-specific expression readouts increase encoding accuracy in both wildtype and mutant populations.

In the absence of any external nitrogen, both wildtype and mutants showed root growth and expanded, de-etiolated cotyledons, but further development was not possible.

FBS stimulated growth of both wildtype and NF1 mutant cells, with mutants having a growth advantage in all axenic conditions.

Specifically, both the wildtype and mutant proteins are localized to the apical domain of adherens junctions in neural epithelial cells.

It was also shown that a calpain inhibitor (ALLM) leads to higher adhesion levels both in wildtype and mutant cells.

The mood stabilizer valproate improved PPI in both wildtype and Sp4 mutant mice.