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The T cell response was evaluated by [H]thymidine incorporation 10 days after immunisation, as depicted in Fig. 5. Here, a proliferative response was demonstrated in animals immunised with unmodified RSA, both when stimulated with the same antigen and when stimulated with the citrullinated antigen.
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AECHL-1 at 5 μM could clearly inhibit capillary tube formation both independently and when stimulated with VEGF (Fig. 2a).
In this study, carboxylic acid-sensitive ORNs displayed both inhibition and excitation when stimulated with these compounds.
CCL12 also plays an inflammatory role because the levels of this chemokine are up-regulated in both microglia and astrocytes when stimulated with the proinflammatory cytokine IL-17 [ 50].
The stimulation index values were lower in group implanted with EDC cross-linked grafts at 15 and 60 days post-implantation when stimulated with both acellular and native antigens.
Likewise, the production of IL-17, TNF-α, and secretion of IL-6 by peripheral blood lymphocytes from patients with type 1 diabetes mellitus (T1D) was reduced, when stimulated with both GAD and GAD-derived prAPL.
Functional studies, carried out on different cell lines, showed that LCA is an antagonist of Eph receptors, because it was able to inhibit the phosphorylation of both EphA2 and EphB4 receptors when stimulated with ephrinA1-Fc and ephrinB2-Fc, respectively.
As shown in Figure 5a, TIM-2 expression was not found on CD4 T cells even when stimulated with both anti-CD3 and anti-CD28 mAbs.
In contrast, CD4 T cells did not express TIM-2 even when stimulated with both anti-CD3 and anti-CD28 mAbs.
Furthermore, recent clinical data show enhanced implantation and pregnancy rates in older women (>35 years) compared with younger women when stimulated with both FSH and LH (Alviggi et al., 2009).
An intriguing finding was that although H69 and H69AR harbour a MET mutation, basal levels of phosphorylation were low in both cell lines and only when stimulated with HGF this phosphorylation increased significantly as well as the oncogenic phenotype.
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