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Our analysis shows that the concentration profiles of the prodrug and its active form may be dramatically different, and hence it is important to look at both when considering the likely effectiveness of the drug.

The STRUCTURE analyses provided strongest support for K = 7, both when considering the probability of the data LnP(D) and Δ K (Additional file 7: Figure S1).

In the NRSF data, all the algorithms performed rather similarly in identifying the validated positive and negative regions both when considering the whole set of detections as well as when focusing on the top peaks only.

We noted that three of the DMRs associated with voltage-gated calcium channel genes (CACNA1S, CACNA1I, CACNA1G) had similar methylation patterns across all children, both when considering the disease-associated DMRs (Fig.  4c) and even clearer when only considering genes involved in axon guidance (Fig.  4d).

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The Stanford Encyclopedia of Philosophy's chapter on Internet Research Ethics indicates that privacy related to an individual's confidentiality and anonymity as well as privacy and security of data is both exceptionally important when considering the ethics of conducting research on the internet (Buchanan and Zimmer 2013).

Clinical consequences for individual affected dogs and the scale of disease-burden at a population level are both of concern when considering the overall impact of pyoderma on canine welfare.

Immunogenicity data in a range of ages and risk groups and systematic monitoring for serotype replacement will both be important when considering the need for future introduction of higher-valency vaccines.

The results changed very little, both when considering all the patients, or separately the patients treated with INX (n = 661, Beta = 0.11, P = 0.0016).

Both errors are worrisome when considering the technology as a potential screening or diagnostic tool in medicine.

The smallest anteroposterior distance between fct and ft centers is similar (2.4 mm) in both Hb1 and Hb4, when considering the three dorsoventral planes.

An inverse correlation was also detected between the Bacteroidetes and the Proteobacteria, despite the fact that the Bacteroidetes showed only marginally significant correlations with both cadmium and pH when considering the structure and diversity levels (data not shown).

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