Sentence examples for both viral replication and from inspiring English sources
These mechanisms are likely to be dose dependent with low gemcitabine doses preferentially inhibiting viral replication and higher doses inhibiting both viral replication and cell proliferation.
Both ribozymes and deoxyribozymes have been demonstrated to block both viral replication and gene expression in experimental systems both in vitro and in cellulo [19] [22].
Overall these findings support the statement that both viral replication and active cellular protein synthesis are required for APP-F formation.
Taken together, our data suggest that autophagy plays a complex, but essential, role in HIV pathology by regulating both viral replication and the fate of the target cells.
However, to the best of our knowledge, these findings represent the first example of a differential cell-type control of autophagy that governs both viral replication and the fate of uninfected cells.
The Akt signaling pathway has been associated with both viral replication and host survival.
It is a pleiotropic protein, involved both in viral replication and in many interactions with cellular signaling pathways, including the interferon anti-viral pathway [ 12].
Thus, it seems clear that HIV-1 and its SIV precursors use Nef and Vpu to fine-tune NF-κB activity during the viral life cycle to achieve both efficient viral replication and immune evasion.
Furthermore, both the markers of viral replication and the T-cells appeared to co-localize in the kidneys to the sites of tissue damage, suggesting that these two together might be responsible for the pathogenesis of hantavirus infection.
Importantly, potent therapeutic efficacy, in terms of both inhibition of viral replication and virtually complete protection from virus-mediated cytopathicity and thymocyte depletion, was also demonstrated in 3TC-treated mice infected with the highly cytopathic R5X4 isolate, JD.
The HCV genome is the template for both protein translation and viral replication and, being RNA, is amenable to direct genetic silencing by RNA interference (RNAi).
