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PVD was selected as the discriminator as it is a composite marker composed of both vessel density and flow data.
Hence, both vessel density and perfusion of the visualized vessels are important.
For example, while both vessel density and vessel size/area were reduced in the chronic treatment, which may implicate suppression of vessel growth and functioning vessels, tumor perfusion only correlated with changes in size/area, not density.
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Vascular morphology of ex vivo rat brains from micro-CT analysis showed hypervascular characteristics in tumors, and both vessel density (41.32±2.34 branches/mm3, p<0.001) and vessel tortuosity (p<0.05) were significantly reduced in tumors of rats treated with dexamethasone compared to saline (74.29±3.51 branches/mm3).
Our study demonstrates that (I) nitroglycerin but not acetylcholine applied topically to the sublingual mucosa increases both total vessel density and local capillary flow velocity in healthy volunteers, (II) without causing measurable systemic effects.
In tumor angiogenesis, loss of Ephrin-B2 leads both to significantly reduced tumor vessel density and to tumor growth [ 11- 14].
This may underlie the observed DKK2-mediated increases in both vessel perfusion and vessel density, and subsequently reduced hypoxia, in DKK2 Tg mouse bearing tumors.
Vessel density and number decreased in both strains from the most central VOI1 to the most peripheral VOI4, (Table 2).
Interestingly, the NMN treatment did not improve blood vessel density and exercise capacity in young sedentary mice.
Total vessel density and perfused vessel density were significantly better in survivors 12 h after ECMO initiation and might therefore help to predict outcomes.
At the same time, they found a strong negative relationship between vessel density and tree-ring width meaning that with wider tree-rings vessel density is decreasing.
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CEO of Professional Science Editing for Scientists @ prosciediting.com