Spreading on soft agar plates was equal in the wild-type and mouse-adapted variants, indicating that both C. jejuni were fully motile (Figure 3a).
Polyclonal antibodies induced by a candidate multi-epitope-vaccine were able to react with the recombinant gp41, respectively, carrying these variants, indicating that "epitope cocktail" strategy is necessary and helpful in vaccine design.
Additionally, we identified CFTR cryptic splice variants masquerading as missense mutations and experimentally validated two "deep exonic" cryptic splice variants, indicating that exonic cryptic splicing may occur more frequently than commonly appreciated.
During the course of natural HIV infection sequential Abs develop that transiently neutralize existing viral variants, only to select resistant escape variants, indicating that Abs can inhibit HIV replication in vivo [1], [2], [3], [4].
No RMSD differences were observed between the Erg9 protein product variants, indicating that the nsSNP acquired by CEN.PK113-7D CEN.PK113-7D no effect on thas3D structure which is in line with the residue-residue interaction network analysis discussed above.
Follow-up sequencing across MAP2K3 identified several paralogous sequence variants indicating that the region may have been duplicated.
All other detected mutations are missense variants, indicating that a complete loss of ECHS1 function may be embryonic lethal.
Recently, we showed loss of helicase activity in several RECQL4 patient protein variants, indicating that the helicase domain is required to prevent disease.
The ptxP1 strains missing BP0910-33, BPP0511-2, BPP2338-47and BPP2338-47 has the most single locus and double locus variants indicating that this is the older type.
