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This finding correlates with enhanced synaptic facilitation and hippocampal LTP in both types of mutant mice.
While expression is significantly reduced in both types of mutant P4 LGNs vs WT, Xu mutants show considerably less expression than Picciotto mutants for at least three probe sets (Table S2), raising the possibility that expression is affected by genetic background in addition to the Chrnb2−/− mutation.
In embryos laid by both types of mutant females, we found a distinct pattern of lamin staining.
Both types of mutant fly walked more slowly than wild-type flies, and showed a more uneven gait with footprints that were less precisely aligned.
Both types of mutant embryos displayed a wide range of abnormalities, among which the formation of free asters was one of the most frequent phenotypes detected in about three-quarters of the laid eggs.
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Both types of mutants have been commonly used as substrates of several protein unfoldase machineries in studies relating protein mechanostability to translocation or degradation rates.
Both types of mutants should be non-motile; however, the motAB mutant should contain intact, yet non-functional flagella, effectively divorcing the presence of flagella from the process of motility.
Both types of mutants have been found in natural populations [ 6, 11].
Both types of mutants have rarely been examined for mammary defects and tumors, and overall phenotypic analysis of single gene mutations has been somewhat hampered by functional compensation from paralogous genes within the complex itself.
Correlating with decreased Nrp1 levels and the NRP1 dose-dependent delay in brain vascularization (see above), Pecam levels were significantly decreased in both types of mutants, with a milder defect in heterozygotes.
In both types of PTPN4 mutant, although the precise nature of the genetic mutation differs, PTPN4 gene expression was shown to be extinguished.
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