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Scanning electron microscopy reveals the interconnected microporous structure of both types of hydrogels.
After 8 weeks of implantation, histological and histomorphometrical evaluation of the subcutaneous scaffolds confirmed the biocompatibility of both types of hydrogels.
As shown in Figure 5 a, no swelling is observed for both types of hydrogels at pH = 3, confirming the complete reaction of all amino groups during the cross-linking.
Figure 5 a shows that both types of hydrogels undergo a similar 5.5-fold change in thickness at pH variations from 3 to 7.4, consistent with the carboxylic group p Ka of ∼5.6 7.
However, the aspect ratios of two types of discoidal capsules, L/ H, at pH = 7.4 remain similar, being 2.8 ± 0.3 and 3.0 ± 0.3 for PMAA and PMAA PVPON, respectively, indicating that both types of hydrogels expand in a similar way in the ionized form.
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The cross-link densities for both types of hydrogel capsules were calculated using the molar ratios of the cross-linkable units within a copolymer chain obtained from H NMR analysis of the PMAA-NH2 or PVPON-NH2 copolymers and their weight-average molecular weights.
We found that both types of peptide hydrogel supported viable mesenchymal stem cells over 48 h.
"The pill is made from two types of hydrogels -- mixtures of polymers and water -- making it softer and longer-lasting than current ingestible sensors," reports Robert Preidt for HealthDay.
There have been many types of hydrogels developed for biomaterials applications.
In addition, we compare the results such as stiffness, degradation time and pore size as well as peptide types of hydrogels from respected journals.
These types of hydrogels are referred to as stimuli responsive and smart hydrogels (Rodkate et al. 2015).
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