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The interventions in both trials were based on pedometer step-count feedback (and accelerometer feedback in the PACE-Lift trial) combined with practice nurse PA consultations.
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At the time, there was widespread belief within republican communities that the trials were based on evidence from witnesses who had been offered deals and cash incentives by the British to spur them into spying.
Two trials were based on alendronate therapy: the Fracture Intervention Trial (FIT) [5] and FIT Long-Term Extension (FLEX) [47]; a third trial was based on zoledronic acid: the Health Outcomes and Reduced Incidence with Zoledronic Acid Once Yearly Pivotal Fracture Trial (HORIZON PFT) [20].
There are no trial data directly comparing stroke risk with varying types and doses of estrogen as existing clinical trials were based on single regimens of HRT.
Ninety-six trials were based exclusively in the US, six exclusively in Canada, and 14 were multinational trials including sites either in Canada or the US, or both.
However, previous results from most controlled trials were based on individuals with cardiovascular disease, limiting their generalizability.
The corresponding authors for almost half (49.0%) of the trials were based in either the United States or the United Kingdom.
43 45 The trials were based on surgical margins measured clinically at the time of wide excision.
Secondly, most trials were based in high risk populations attending sexual health clinics.
The two linked trials were based in emergency departments 16 and probation offices.
All trials were based on intention to treat analysis of long term treatments.
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