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Both trials failed to show significant benefits over placebo in either measure.
Of interest, subset analyses in both trials failed to demonstrate improved PFS for the poor risk patient subset, which represented a very small group (<10%) in both trials.
32, 33 Both trials failed to show an overall survival (OS) benefit; however, a pooled analysis of these two studies, presented at the American Society of Clinical Oncology meeting in Chicago in 2014, 34 showed a survival advantage of 3 months for patients treated with afatinib compared with the chemotherapy arm.
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Finally, a meta-analysis by Perel and colleagues [ 8], which included both SAFE and VISEP trials, failed to show differences in mortality in hospitalized patients but recommended that future trials focus on specific subgroups.
Both phase II trials failed to satisfy their primary endpoints, suggesting a certain inability to induce remission.
Both of these trials failed to demonstrate any benefit of EGDT or protocolized resuscitation when compared with 'usual care'.
Both probe and latency trials failed to show any significant difference between Rac inhibitor-treated (NSC23766) and vehicle (sham) control (non-ischemic) animals in locating the hidden platform or navigating towards the goal quadrant.
Unfortunately both in dysferlinopathies and in FSHD, steroids' clinical trials failed to ameliorate or delay the disease progression [ 30].
Although both steroidal and nonsteroidal anti-inflammatory products were extensively tested, randomized clinical trials failed to demonstrate efficacy in AD [ 46].
But trials failed to show a benefit over placebo.
She thought the trials failed to understand the man and his deeds.
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CEO of Professional Science Editing for Scientists @ prosciediting.com