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PET imaging was performed with both tracers in all three xenograft models to determine whether the irreversible inhibitor shows better tumor targeting.
There was 100% concordance as to the absence or presence of uptake of both tracers in all tumours under study with five patients displaying a lack of uptake of either tracer preferentially in low-grade tumours.
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First, injections of retrograde tracers in all prefrontal cortical layers labeled retrogradely thalamic projection neurons in the ventral anterior nucleus that projected to all cortical layers.
From these results, no significant difference was observed between both tracers in terms of muscle accumulation.
However, liver uptake was significant and comparable for both tracers at all time points with both tracers showing a slight liver washout (MIBI, 16% vs. TETRO, 23%, p = 0.48) in the imaging interval.
However, liver uptake was significant and comparable for both tracers at all time points.
The level of tracer accumulation in all regions of S1R-KO mouse brain was comparable with that observed in muscle.
Tumor uptake of [64Cu]NOTA-pentixather was significantly higher than tracer accumulation in all other organs (13.1 ± 1.5% ID/g), underlining its excellent CXCR4 targeting efficiency.
The specificity of [68Ga]3 for integrin αvß3 was confirmed in blocking studies by co-injection of an ~100fold excess c RGDfK), which resulted in a significant reduction of tracer uptake in all tissues (P values < 0.05 for all tissues).
F-FDG PET/CT showed pathological tracer uptake in all nine patients with proven septic thrombophlebitis.
Decristoforo and coworkers compared the biodistribution of [Ga]DOTA-RGD, [In]DOTA-RGD and [F]Galacto-RGD and found that [Ga]DOTA-RGD had the highest tracer uptake in all organs [ 13].
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