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Representative PET images of both tracers are shown in Fig. 2.
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The renal extractions of the three tracers are shown in Figure 3.
Whole-body distribution volumes (normalized to body weight) of the different tracers are shown in Figure 3A.
The magnitude of the negative sensitivities for glucose tracers are shown in Additional file 3, Figure 1A.
Confidence intervals for the optimal and other representative tracers are shown in Additional file 4. For the oxPPP flux, several other tracers had confidence intervals that approached but did not outperform [2,3,4,5,6-C]glucose.
The relative uptake and distribution of the three tracers is shown in Figure 6.
The concordance of ischemia diagnosis sensitivity of a representative patient for the two tracers is shown in Figure 4.
In particular the dispersion of an initially sharp pulse of tracer is shown to be somewhat less than would be calculated for a non-expanding fluid with the same properties at entry.
In studies performed by our group the favourable pharmacokinetic parameters of this tracer were shown [ 7].
Upon injection, the tracer was shown to be heterogeneously distributed in healthy rats but unfortunately no evaluation in animals bearing a hypoxic tumor was reported.
Both tracers have been shown to accurately quantify MBF in absolute units over a wide flow range and correlate well with values obtained after injection of radiolabeled microspheres, both at a regional and global level [ 9].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com