Tissue morphogenesis involves both the sculpting of tissue shape and the positioning of tissues relative to one another in the body.
Embryonic development involves global changes in tissue shape and architecture that are driven by cell shape changes and rearrangements within cohesive cell sheets.
The same could be true for genes contributing to maintenance and modification of tissue shape and structural identity, e.g., versican, tenascin, and ADAM12 (Fig. 1, 2 and 4).
Here we describe how altered intercellular adhesion mediated by FasIII plays a key role in the development of tissue shape and in particular curvature in epithelially derived organs.
MT behavior would thus depend on two parameters of mechanical stress: stress direction from cell and tissue shape determine the dominant MT orientation, which dictates wall reinforcement, and thus in turn contributes to cell and tissue shape; and stress intensity modulates severing activity, which controls the response of MTs to stress.
Single confocal images (Fig. 1B-F) from a representative dataset show membrane and nuclear labeling; volume renderings (Fig. 1B′-F′,B″-F″) illustrate changes in tissue shape and size.
Additionally, complex morphogenetic processes are also required to sculpt the resulting cells and generate the final tissue shapes and structures required for organ function.
Finally, we compare predictions of this theory to the experimentally measured cell and tissue shape changes and determine key biophysical parameters characterizing tissue material properties.
As bladder is a highly distensible tissue, bladder sections prepared from individual animals varied greatly in tissue shape, folding and thickness, making quantitation with image analysis problematic.
Note that this viscosity was not included in Equation 3 in the main text, but is used in the fitting procedure described in 'Fitting of the rectangle model to cell and tissue shape in the hinge and blade'.
