Adding time 2 triglyceride levels resulted in nine groups cross-classified according to triglyceride level at both time points, for which the HR for diabetes was calculated and expressed using individuals in the low tertile of triglyceride levels at both time points (low-low) as the reference group (Fig. 1 A ).
The following measurements were made using the fasting blood samples and standard enzymatic kits at both time points: plasma glucose, total cholesterol, HDL-cholesterol, and triglycerides.
Conversely, in those whose triglyceride levels decreased from the high to the low tertile, the HR for diabetes was 1.56 (0.33–7.40), not significantly different from that for those who retained low triglyceride levels at both time points.
Exemestane had a nonsignificant trend to increase LDL cholesterol levels at 3 and 6 months, but reduced triglyceride levels at both time points and by about 10% at 6 months (Markopoulos et al, 2003).
In this model, dynamic changes in triglyceride levels remained a significant modifying factor of the risk of incident diabetes: individuals whose triglyceride levels progressed from the low to the high tertile had a HR for diabetes of 7.32 (95% CI 2.62 20.70) compared with those remaining at the low triglyceride tertile at both time points.
In the multivariate model, which now also controlled for the time interval between time 1 and time 2, the HRs for diabetes were 3.17 (95% CI 1.09 8.67) and 7.08 (2.52–14.45) in individuals with triglyceride levels at both time points in the intermediate- or high- tertile levels, respectively.
Women who were excluded because they had not performed the fasting blood samples at both time points were heavier and younger and had higher enrollment glucose and HbA1c (but not triglycerides) than those who were included (data not shown).
This is reflected by the facts that 1) individuals with initial low but subsequent high triglyceride have a higher HR even compared with those with stable high levels at both time points and 2) in the high-low group, which exhibited positive lifestyle changes, a HR statistically indistinguishable from that for those with stable low triglyceride levels was observed.
All fibrils had similar diameters at both time points.
Pictures were taken at both time points.
