Of these genes, 116 were up-regulated and seven down-regulated at both time points, suggesting that most genes up-regulated at the early stage of infection tended to be constantly up-regulated at the later stage whereas the landscape of the down-regulated genes differed significantly at the two time points investigated.
pIP3R protein was upregulated at both time points, suggesting changes in the IP3 channel activity on the ER membrane.
Downregulation of muscle genes at both time points suggests that the differentiated muscle gene expression phenotype changes by 5 dpa, and changes more dramatically by 14 dpa.
More genes were affected by protons than by photons at both time points, suggesting that these relevant genes are more susceptible to protons.
The survival of CCD-34Lu and A549 cells was very similar at both time points, suggesting that these cell lines did not recover during post-treatment incubation and the toxicity induced by NP treatment persisted for long time.
In all, 59 (84%) of the down-egulated and 48 (65%) of the upregulated proteins were changed at both time points suggesting that most of the PD changes were durable for at least 13 weeks.
As regards connectivity, interhemispheric alpha coherence was higher in the dyslexic group compared to the control group across both time points, suggesting that increased alpha coherence may reflect a compensation mechanism ([ 80]; and for additional details see [ 66]).
These data show normal distribution of markers in the subplate (Nurr1), through layers 4 6 (Ctip2, Foxp2, and Tbr1) to the upper layers 2 3 (Sand2 and Cux1) at both time points, suggesting that no overt patterning or migration defects occur in the cortex of Visc-2−/− mice.
We found that in terms of disturbance on the GHQ-28 that the group with cough a follow-up only was not significantly different from those with cough at both time points, suggesting there may be little effect of chronicity over our follow-up period of 4 to 5 years.
The detection of transcripts for a diverse number of genes in antisense orientation by LongSAGE at both time-points suggests strong involvement of antisense transcripts in regulatory processes during B. napus seed development.
