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In both the simulation studies and the fMRI data applications, we demonstrate that the proposed methods provide more accurate prediction and more reliable estimation of individual functional connectivity as compared with alternative methods.
In both the simulation studies and the evaluation of the method using real data that follows, training genotypes were standardised to correlation form, and in the continuous case the responses were centred, prior to model fitting, as described in methods section.
In fact, even though the sensitivity was modest, both the simulation studies and the real breast cancer datasets suggest that our approach detects many of the strongest associations with very high specificity.
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Both the simulation study and real case analysis with NDNQI quarterly report data demonstrated that the consequence of omitting a structural effect from the Box-Cox power transformation was limited.
However, estimates of the heterogeneity of risk among cities are unstable, with zero values frequently occurring, both in the simulation study and in the analysis of real data.
Thus Protocol II tests for a much more informative null hypothesis than the statistical test in Protocol I. Notice that the four factors affecting power we identified earlier affect both null hypotheses and have noteworthy effects on both protocols as shown in the simulation studies.
For both experiments in the simulation study, the BRT model had a smaller interaction depth of 2, rather than 5 that was used in the case study analysis, as the simulation study data set had far fewer variables.
The simulation studies are performed using GEMS simulation software [21].
AMC conducted the simulation studies.
CB performed the simulation studies.
This was confirmed in the simulation studies.
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