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The presence of metastases and complete surgical remission emerged as significant prognostic factors for both the sarcoma types.
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Interestingly, this mutation was detected in both rhabdomyosarcoma and angiosarcoma histologic sarcoma types.
These specific factors may be the specific translocations that define certain sarcoma types; alternatively, the cell lineage-dependent genetic content may establish the sensitivity or resistance to a specific drug activity.
Combined application of SCH and Hsp90 inhibitor also induced the apoptosis of other sarcoma types but did not affect the survival of normal osteoblasts.
The versatile property of PTs to convert into various sarcoma types is reminiscent of the features of mesenchymal stem cells (MSCs).
A total of 11 of 21 sarcoma types represented in the cohort developed extra-pulmonary metastases (Table II).
Relatively prevalent sarcoma types (n > 5) within the cohort that when metastatic disease had a higher percentage (> 20%) of abdominal or pelvic involvement, were epithelioid sarcoma, leiyomyosarcoma, liposarcoma, spindle cell sarcoma, and synovial sarcoma.
The European Organisation for Research and Treatment of Cancer Gynaecological Cancer Group Study proposed a trial to evaluate the treatment effect of adjuvant radiotherapy on all uterine sarcoma types.
It is possible that one of the activities of these compounds is dependent on specific factors present in some sarcoma types.
We designed a NanoString assay targeting 174 unique fusion junctions in 25 sarcoma types.
Gene expression profile comparison of SS to other sarcoma types has helped identify a handful of genes that are preferentially associated with SS [22] [24] and suggests the implication of several signaling pathways in SS pathogenesis, including receptor tyrosine kinases, Hedgehog, Notch, RAR, TGFβ and Wnt [25] [29].
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