Sentence examples for both the original ATP-binding from inspiring English sources

Type II inhibitors often occupy both the original ATP-binding pocket and the allosteric pocket.

The purine portion of the inhibitor binds to the adenine binding pocket of the enzyme, even if rotated with respect to the original ATP conformation.

Thus PEITC inhibition of MEKK1 requires both access to the ATP-binding pocket of MEKK1 and the cysteine at position 1238.

Thus, the conservation of both the ATP binding and the peptide binding domains in GRP78va suggests that it can act as a cytosolic counterpart of canonical GRP78, interacting with client proteins playing critical roles in cell survival.

Both the original and updated ATP III definitions were applied in 689 Americans with schizophrenia, who participated in the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) Schizophrenia Trial.

Intriguingly, the compounds have a dual inhibitory activity by functioning as both ATP and JIP mimetics, possibly by binding to both the ATP binding site and to the docking site of the kinase.

Moreover, the biochemical characterisation of a recombinant ABCR protein with the p.Arg1129Leu mutation revealed a substantial reduction in both expression and ATP-binding activity.

Both, the permease domain and the ATP-binding domain are homo- or heterodimers, and depending on the transporter, encoded by 1 to 4 different genes.

Kinesins are defined by their motor domains that contain both the MT and ATP binding sites.

These data indicate that both PP2A- and ATP-binding are required for the function of PTPA in PP2Ac activation.

Both inactive ATP-binding site conformations are characterized by displacement of at least one conserved catalytic residue from the active site and disruption of the regulatory hydrophobic spine.