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Models of both the input function and tracer movement between the blood vessel and the surrounding tissue can be simultaneously fitted to a total regional TAC taken from the vicinity of the blood vessel in the dynamic PET images.
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An example of a blood-sampled input curve is shown in Figure 2, together with a fit of Equation 4. Simpler mono- and bi-exponential models of the input function (both with a time-delay parameter for tracer delivery) were also tested but could not adequately describe the blood-sampled input functions.
However, the input function for both tracers can be retrieved relatively simplified and noninvasively from the image data with good accuracy according to methods already reported in literature [21 23].
The analyze argument is a function of two arguments, the generator and the input function.
Comparison of VOI data and input blood data (input function) showed that bolus of the input function appeared slightly later than the bolus in the VOI data.
The input function (primary m-sequence) was balanced to have a mean of zero.
n determines the steepness of the input function (Alon, 2007).
For b>>1, the input function displays dichotomic behavior.
A simplified kinetic method (SKM) is advocated [ 96], assuming a uniform input function, based on fitting the input function of control patients with a triexponential decay function.
Further studies are needed to investigate whether an image derived input function can replace the input function obtained by arterial blood sampling.
GLM analysis in this subgroup showed neither an effect of input function (F = 2.05, p = 0.186) nor a cross effect between the input function and region.
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