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Strengths of the study include the relatively long-term follow-up in terms of intermediate outcomes, the use of multiple imputation to address the large amount of missing cost data, the use of both the friction cost approach and the human capital approach to value productivity losses, and the application of a randomized controlled design in a real-world setting.
To address productivity loss, both the friction cost approach and the human capital approach are suggested [ 12, 23, 35].
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Absenteeism will be valued using both the friction-cost method (primary analysis) and the human-capital method.
For paid labour, the costs will be calculated, using both the human capital approach and the friction cost approach.
For all cases of influenza-like illness we used the friction cost method for the Netherlands and the human capital approach for the other two countries.
Costs from productivity loss will be quantified using the friction cost method, as recommended in the Netherlands [ 28].
Direct cost data were derived from the Danish Maritime Authority while for indirect costs estimations were applied using the friction cost approach.
There are two commonly used methods: the human capital approach (HCA) and the friction cost approach (FCA).
This fact served as an additional argument to not employ the friction cost approach in our study.
If it breaks down, the friction cost is going to be high.
Subsequently, the friction cost method was used to monetarily value the indirect costs [42], [43].
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