In this connection, we have conducted several site-specific chemical modification studies with human lysozyme for the purpose of both the alteration of substrate specificity [ 12] and the clarification of the origin of carbohydrate recognition specificity [ 13].
Our observations in the acute post-injury phase may inspire potential neuroprotective therapeutic strategies, since both the alteration of ion current regulation and the activation of retinoid signalling can be pharmacologically modified.
In both systems, the alteration of RACK1 expression alters miRNA function and impairs the association of the miRNA complex with the translating ribosomes.
In both cases, the alteration of the spatial domain of an existing gene expression pattern formed the basis of an evolutionary innovation.
Thus, chronic GC treatment in 21-OHD patients may contribute both to the alteration of bone resorption and formation [ 66, 67].
Although the two nitrogen-containing bisphosphonates differed in their capacity to induce apoptosis and to inhibit cell proliferation, a prominent effect of both was the alteration of the progression of melanoma cells through the phases of the cell cycle.
Design and development of suitable multilayered systems for delaying corrosion advance in metals requires that both the alteration mechanisms of the metal and the behaviour and properties of the protective coatings be known.
The alterations of both AChE forms observed in diabetic state could be attributed to hyperglycemia and lipid peroxidation that triggered brain dysfunction by disturbing the neurotransmitter acetylcholine level.
Thus, it is concluded that the alterations of both pore structure and oxygen-containing functional groups due to CO2 exposure contribute to the decrease of CO2 diffusion-adsorption rate.
These results conform to the assertion that SOC stocks are sensitive to land use and cover change (Guo and Gifford 2002; Wiesmeier et al. 2012) probably because of the alterations of both carbon inputs (amount and quality of litter mass) and losses (decomposition and mineralization).
