Sentence examples for both the alteration of from inspiring English sources

Our observations in the acute post-injury phase may inspire potential neuroprotective therapeutic strategies, since both the alteration of ion current regulation and the activation of retinoid signalling can be pharmacologically modified.

In this connection, we have conducted several site-specific chemical modification studies with human lysozyme for the purpose of both the alteration of substrate specificity [ 12] and the clarification of the origin of carbohydrate recognition specificity [ 13].

Both the alterations of the mTOR signalling cascade in AD brain and the outcome of the lymphocyte test were independent of the ApoE status of the patients.

In both systems, the alteration of RACK1 expression alters miRNA function and impairs the association of the miRNA complex with the translating ribosomes.

In both cases, the alteration of the spatial domain of an existing gene expression pattern formed the basis of an evolutionary innovation.

Thus, chronic GC treatment in 21-OHD patients may contribute both to the alteration of bone resorption and formation [ 66, 67].

Although the two nitrogen-containing bisphosphonates differed in their capacity to induce apoptosis and to inhibit cell proliferation, a prominent effect of both was the alteration of the progression of melanoma cells through the phases of the cell cycle.

Design and development of suitable multilayered systems for delaying corrosion advance in metals requires that both the alteration mechanisms of the metal and the behaviour and properties of the protective coatings be known.

Since Cry2Ab and Cry2Ae, but not Cry1Ac, share binding sites in both Helicoverpa species, the alteration of the receptor for Cry2A proteins is expected to confer resistance simultaneously to these two proteins without affecting the insect susceptibility to Cry1A proteins.

This reprogramming of differentiation state is evident in BL31 both in the alteration of many transcription factors (Figure 4; Table S3) and the enrichment for germinal centre transit genes (Table S4).

The effects of exposure of perlecan to peroxynitrite was explored by examining both the alteration in the binding of antibodies that recognize specific epitopes on the protein core (domains I, III and V) and the HS chains, and specific oxidation products (3-nitroTyr and carbonyls) that may result from oxidative damage.