Sentence examples for both the activation of from inspiring English sources

Indeed, we demonstrate that perifosine and edelfosine inhibit both the activation of Akt and the kinase activity of Akt in HIV-1 expressing human microglia cell lines, and perifosine effectively induces the death of HIV-1 infected macrophages.

Several other reports also show that certain reagents including STS can induce caspase 3 activity and apoptosis through both the activation of caspase 8 and caspase 9 [ 31- 35].

KN-93 prevented both the activation of cdk4, and this shift in cyclin D1 migration and overexpression of cyclin D1/cdk4 overcame the KN-93 arrest.

These results confirmed the translation advantage of the EV71 5′-UTR-led translation over the cellular EIF3C 5′-UTR-controlled translation in EV71-infected cell, caused by both the activation of cap-independent translation and suppression of cap-dependent translation.

In the current study, CSE induces the release of chemokines by both the activation of NF-κB and the MAPK pathways since inhibition of these intracellular signaling pathways suppresses the release of both chemokines.

Indeed, while wortmannin (WT) inhibited both the activation of Akt (Fig. 4B, top) and SphK1 (Fig. 4B, bottom) induced by DHT, the SphK1 inhibitor SKI-2 did not impact Akt phosphorylation (Fig. 4B, top).

These results demonstrate that events during the early phase of MVA replication can induce PKR-mediated processes contributing both to the activation of NF-kappaB signaling, and to processes that may restrict viral replication.

However, deletion of RTS1 and CDC55, encoding the regulatory subunits, both influenced the activation of PP2A.

Upregulating miR-646 or downregulating NOB1 expression can both inhibit the activation of the proteasome.

Mitochondrial pathway activation results both in the activation of Caspase-3 by Caspase-9 and also relief of Caspase-3 inhibition by the protein DIABLO [ 8].

Inclusion of one or the other in two different signatures apparently converges at the pathway level both indicating the activation of the estrogen-signaling pathway.