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Activated CD4+CD8+ lymphocytes, macrophages, and dendritic cells express widely VDR and both the activating and metabolizing enzymes, 1- α hydroxylase and 24-hydroxylase [ 94, 95].
These results establish that both the activating and repressive effects of GW3965 under our experimental conditions are entirely mediated by LXRs.
Interestingly, substantial enrichment of nonprotein kinases over protein kinases was observed in both the activating and suppressive pools of candidate genes (white bars; Figures 1D and S1A).
On the other hand, when the DNA contained a lot of As and Ts, the chemical marks were added directly to the DNA (rather than to the chromatin)—and this prevented both the activating and the inactivating chemical marks being added to the chromatin.
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The distribution of these two groups of genes among GO categories is very similar concerning both the activated and the repressed genes.
Summation of both the activated and deactivated hemodynamic responses in the NIRS channels of the SI area might result in non-significant hemodynamic responses in the ipsilateral SI area.
Characterizing the role of any GPCR involves the identification of both the activating ligand and the activated G protein.
Taken together, it appears that both the activating ligand and the composition of the ErbB dimer induce conformational changes that ultimately dictate the choice of carboxy-terminal tyrosines transphosphorylated by the ErbB kinase domains.
MAX is MYC's dimerization partner and is required for both the transcriptional activating and suppressing functions of MYC [ 28].
Mice were sacrificed at E16.5 for the detection of both the activated Caspase 3 (Cand3a) and the YFP markers.
The pathologist was blinded to the ELISA results and survival data during scoring of both the activated caspase-3 immunohistochemistry and the microscopic assessment of tumour necrosis.
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