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These included the six patients (21 %) in which both tests were concordant positive and ten patients (34 %) were both tests were concordant negative.
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At delivery, the results of the two tests were concordant for both the maternal peripheral blood smear and the placental blood samples in the two groups.
The results obtained with the 3 tests were concordant in 58/82 samples (70%).
The LA and LQ tests were concordant in detecting the majority of HR-HPV genotypes except HPV35, HPV53, HPV59, and HPV73.
Performed on each of the 127 samples, the results of these four confirmatory tests were concordant in 115 samples (61 concordant positive, and 54 concordant negative), and discrepant in 12 samples.
Nevertheless, while for the total set of networks included in the Venn diagram in Figure 2 (all pathways that are significant at least in a single test) in 31 cases row and column permutation tests were concordant according to an alpha level of 0.05 and further 26 pathways were rejected by both strategies, in as much as 22 cases discordance between row I and column permutation tests was observed.
Thus, significance based on the randomization tests was concordant with the p-values from the regression analysis.
The Seattle assay was more variable, but the majority (16 of 28) of tests was concordant with the Toronto result.
A possible bias in our latent class etimates might occur if the additional Cobas TaqMan CT and PCR tests are systematically different when the BDPT tests are concordant, respectively discordant.
Although for patients with HIV infection a low concordance was noted between non-invasive methods for the diagnosis of fibrosis, in coinfected patients it was moderate and these tests could be used as evaluation methods in the monitoring of liver injury especially when the results of these tests are concordant.
In our study, two new candidates tested were concordant at P < 0.05 by both approaches, in at least one of the tissues (2610029G23Rik and Pnck).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com