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GMixBayes is modified from earlier GEO-adjusted methods in two aspects: estimation of prior variance using Gaussian mixture model and Bayesian integration of both testing and reference dataset variances.
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Both test and reference formulations appeared to be generally safe and well-tolerated in all the subjects.
Biphasic absorption pattern was observed in the plasma profile of some volunteers for both test and reference formulations.
We use the same voxel resolution for both test and reference mesh sequences.
Invariants calculated from both test and reference field shapes are compared to determine the similarity between two treatment fields.
In general, 3NN achieves high PR' in the internal validation, which is partially attributed to the close analogues that exists in the both test and reference sets.
Both test and reference formulations of the rhGM-CSF were designed for either oral or subcutaneous administration in both RT and TR groups.
Both test and reference DNAs were then labeled with Cy-5 and Cy-3 dUTP derivatives, respectively and hybridized to a custom made DNA tiling microarray containing 50 60 nt DNA probes staggered in 50 60 bp steps and spanning a total of 33.5 Mb of human DNA (Supporting Tables S1).
In the supplementary notes of their paper the authors say: "We included for subsequent analysis only well measured genes whose expression varied, as determined by (1) signal intensity over background >1.5-fold in both test and reference channels in at least 75% of samples, and (2) 3-fold ratio variation from the mean in at least two samples; 5,153 genes met these criteria".
Thus, profiles are robustly conserved across technical replicates of both test and reference DNA.
Both test and reference samples were labelled with cyanine-5 (Cy5 -labelled Cy5 -labelledmer InCTP Waltham, MA, USA).
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