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Limitation for the validity of the biomarker might be the homogeneity in both test and validation cohorts, all white individuals from Spain.
Both test and validation sets were analyzed using the SDS 2.3 software (Applied Biosystems).
The model demonstrated good performance in both test and validation population.
However, the premenopausal subgroup in both test and validation sets comprised only 15%to20%0% of cases, so further studies are needed to confirm this finding.
Our data showed a strong correlation between ELISA and MS results in both test and validation sets, reflecting reliability of MS and isotopic labeling for protein quantification.
Figure 4 shows after adding new features, the correlation between the objective values and the model output values improves significantly in both test and validation sets over the control models.
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Results by logistic regression a in Testing Set, b in Validation Set, c in both Testing and Validation Set; a, b, c Adjust for age, age at menarche, menopausal status and age at first live birth.
This approach has seen considerable attention in the biodiversity realm, with both tests and validations (26 – 28 ), and with broad applications across faunas and floras (29 – 329).
Univariate analysis showed that tumor size (≤10, > 10 cm), mitosis count (≤10, > 10/50 HPF) and serosal invasion were prognostic predictors for RFS both in the test and validation cohort.
Both the test and validation data should adequately bound the types of data likely to be encountered in the industrial application of the net.
Overall, the results not only demonstrated that the models employed successfully simulated chl-a in a reservoir in both the test and validation periods, but also suggested that the optimal parameters should cautiously be considered in the design of regression models.
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