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When both substituents are unreactive alkane fragments, as in ketones, there are few reactions other than carbonyl additions.
One of the more common is shown here; reactions in this category consist of replacement of a group designated Y (often a hydrogen atom) in an aromatic molecule by an electrophilic agent designated E. Both substituents can be any one of various groups (e.g., hydrogen atoms or nitro, bromo, or tert-alkyl groups).
Both substituents in combination are essential for its improved efficacy (Wetzstein and Hallenbach 2011).
Varying both substituents on the ylidene malononitrile and the ketone reagents resulted in a variation of the substituents on positions 4 and 6 of the pyridine ring.
analysis showed that both substituents are effective in lowering the crystal melting and low-temperature crystal-crystal transitions with respect to the diethylsiloxane homopolymer, and ultimately lead to non-crystalline copolymers.
D.s.c. and dynamic mechanical analysis show that both substituents are effective in lowering the crystal melting and low-temperature crystal-crystal transitions with respect to the diethylsiloxane homopolymer, and ultimately lead to non-crystalline copolymers.
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However, querying a chemical database with both substituent constraints and mass constraints is very difficult.
Based on the design and synthesis of 10-hydroxybenzo[h]quinoline (3) derivatives, we demonstrate a prototypical system to investigate both substituent and conjugation effects on excited-state intramolecular proton transfer emission through a combination of experimental and theoretical studies.
A reaction mechanism is proposed which is consistent with the experimental data; the effect of the supporting electrolyte, the addition of protons and the role of substituents both in the phenyl ring and in the acyloxy groups have been taken into account.
The computed structure of this species is shown in Figure 3 and displays the anticipated hydrogen-bonded chair-like structure with the Au and both Me substituents all occupying equatorial positions.
A search revealed 115 CA structures with 124 ligand conformations in which the active center zinc-bound sulfanilamide group is attached to a benzene ring with both hydrogen substituents at the orthoposition.
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