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Biomarkers are already employed in clinical trials in prodromal AD for both subject selection and in monitoring therapeutic response.
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First, we discuss considerations for subject selection and characterization, including issues related to comorbid conditions, medication status, and clinical assessment.
Subject selection and recruitment.
PGG participated in the study design and subject selection and is currently participating in outcome measurements.
Detailed information on subject selection, and inclusion and exclusion criteria are listed elsewhere [ 18].
MJSI participated in the study design and subject selection and is currently participating in outcome measurements.
Finally, studies that insufficiently described subject selection and statistical procedures were excluded (n = 1 [ 51]).
The sample size calculation, subject selection and sample division were performed with Epidat 3.1.
The process of subject selection and randomization is shown in Figure 1.
The details of subject selection and study design have been described previously [ 19].
Earlier papers have a detailed description of subject selection and enrollment procedures [ 4, 8].
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