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Characteristics of both study populations are presented in Table 1.
Full details of both study populations are available in Additional file 2: Supplementary Materials.
Both study populations are highly selected because already enrolled in phase I trials, we plan to conduct a new study in a cohort of patients screened for phase I trial participation.
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Because trastuzumab has been known to cause incremental myocardial injury when used in conjunction with ACs [28, 29], both study populations were at higher risk of cardiotoxicity.
This age filter generated an older CSSCD study population that was comparable to the NIH; one third of both study populations were comprised of subjects aged more than 45 years (Figure S1).
The age-specific overall prevalence of ≥ 2 diseases for both study populations is shown in Figure 1.
In Figure 2, the age-specific overall prevalence of ≥ 3 diseases for both study populations is shown.
Baseline SF-36 scores in both study populations were lower than those of an age-matched and sex-matched US population.
Consistent results for both study populations were only found for one intronic TFRC SNP: The A allele of rs3804141 was associated with increased U-Cd concentrations.
Both study populations were too small to stratify the patients according to covariates, such as gender or treatment joint/area, to obtain statistically relevant data.
Demographic variables in both study populations were summarized and compared using the Student's t-test for numeric variables and chi-square tests for categorical variables.
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