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It is reassuring, however, that the results from both study pools were concordant.
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Overlapping between the study pools is another limitation.
The individual effect sizes were then weighted, indicated by ES in this study, and an overall weighted mean effect size of the study pool was calculated.
Second, the study pool is mammoth and long-term.
Nevertheless, as already mentioned, it has to be taken into account that our study pool is a composite of quite different studies.
The IRs in the 20-study pool were higher with saxagliptin vs placebo or comparator for bone fractures and hypersensitivity AEs.
This second approach is proposed when the number of studies pooled is small, and there is toxicological or clinical literature to support a causal relation.
But earlier this month, the Nuclear Regulatory Commission said the study was wrong and the pools were not vulnerable.
As no difference between the clinical efficacy of the empirical antibiotic regimens was detected, the data of patients in both study arms were pooled.
Puromycin-resistant cell pools were used in this study.
The puromycin-resistant cell pools were used in this study.
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