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Both studies were single arm by design.
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Both studies were single-arm, open label phase II studies.
As both studies are single institution and non-randomised, their results are less reliable and may reflect a referral bias.
Twenty-five studies were single centre.
All studies were single center based.
Eleven of the studies were single studies investigating different proteins.
Half of the studies were single cross-sectional surveys.
Most of the studies were single center studies with a limited number of patients.
However, these studies were single administration studies on non-clinical outcome measures.
Previous studies were single institution studies using retrospective design [ 17, 32, 33, 36].
However, most studies were single center investigation based on relatively small samples.
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