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Both studies were relatively small and did not have other biomarkers of tobacco smoke exposure that allowed for comparison to meconium results.
We are aware of only two other case-control studies of cryptosporidiosis in non immune-compromised personon immune-compromisedustrialized nation (7, 8); both studies were relatively small.
Regarding patient characteristics, while both studies were relatively small, our study had nearly twice as many participants enrolled (n = 264 v n = 96) and our average length of follow up was nearly twice that of the prior study (40 months v 24 months).
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Furthermore, both studies are relatively small, indicating the need for more detailed investigations in humans of metal and epigenetic modifications.
It should be noted that, the sample size of both studies was relatively limited and so associations can not be ruled out for rs731236 (TaqI), and rs2228570 (FokI), particularly in MM.
It is noteworthy that both individual studies were relatively small and that the largest single study in this analysis (with a sample size over 6-fold greater than the combined sample size of the two previous studies with presence of effect modification) had the largest P-value for interaction.
As both of these studies were relatively small, their findings in isolation would be considered preliminary evidence.
Both of these studies were relatively small and were undertaken in non treatment-seeking heavy drinon treatment-seekingtreatment-seeking patients diagnosed witheavy.
Of note, both of these studies were relatively short in duration and drug exposure (median follow-up, respectively, 2.1 and 1.5 years) and included patients predominantly, or exclusively, with manifest CV complications.
These studies were relatively small in nature.
Logistical issues have meant that these studies were relatively small.
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