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In both studies we observed a significant association of the imputed T allele of rs2228671 with CAD risk resulting, expectedly, in decreased ORs for disease manifestation (Fig. 4).
In both studies, we observed considerable variations in male reproductive success.
In both studies, we observed effects on asthma from NO2. Notable strengths of this study are the prospective design, individually measured pollutant exposures, incident disease assessment, and the large effects.
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In both studies we observe the induction of oxidative stress proteins such as glutathione S-transferases, proteins involved in necrosis such as vacuolar H+ ATPases (predominately in the last time-points of infection) and galactose binding lectins.
In comparison to both previous studies, we observed a higher overall rate of VTE.
In both of these studies, we observed >50% (sometimes >90%) reduction in effect estimates for many associated SNPs.
In our studies, we observed both PPARγ and the adipocyte marker aP2 were highly regulated in adhesion cultures, suggesting that adhesion cultures positively influenced adipogenesis while suppressing osteogenesis.
During functional studies, we observed that both the spliced ORF57 mRNA and a cellular, spliced mRNA (β-actin) remained relatively unaffected by siRNA-mediated PYM depletion.
In keeping with our murine studies, we observed that both NFAT- and NF-κB-dependent signalling pathways contributed to the inflammatory response to AF in human alveolar macrophages (Fig 9B).
When haplotypes encompassing both SFTPA genes were studied, we observed 39 of the 64 expected haplotypes, and only 14 haplotypes had frequencies higher than 1% (data not shown).
In this study, we observed both in DIGE and Western blot assays that microglia expressed significant less PP2A when co-cultured with astrocytes compared to its expression in the absence of astrocytes, regardless of microglial infection status.
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