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This indicates that the pKa of Cys24 is shifted significantly toward neutrality in both structures, consistent with its role in forming a disulphide bond with GSH [ 42].
WNK4 Gln was disordered in both structures, consistent with a lack of stabilizing side-chain contacts, yet was critical for peptide binding.
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Both docking studies led to predicted interface structures consistent with known mutant binding properties and were used to select residues for site-directed mutagenesis.
"You've got to create the structures consistent with what your temperament needs to be," he said.
StrucEluc attempts to generate a set of candidate structures consistent with the data.
Autolysosomes and vesicular structures consistent with autophagy were detected in cells treated with bio-AgNPs (E) and chem-AgNPs (F).
In the Bgn−/0/Lum−/− corneas there were abnormal lamellar and fibril structures consistent with the functional deficit in transparency.
Therefore, it is desirable to enumerate all chemical structures consistent with a given feature vector and the valence condition (specified by val.
Immunofluorescence analyses showed that recombinant mouse IFN-γ localised to discrete punctuate structures consistent with dense granules and secreted into the vacuolar space.
Myc-Rev expressed alone accumulated in nuclear structures consistent with nucleoli, as observed previously [23] (Fig. 5).
Fourteen of the hybridomas secreted antibodies that stain apical, club-shaped structures consistent with the rhoptries (Figure 5A, B) [5], [12].
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CEO of Professional Science Editing for Scientists @ prosciediting.com