Some "Domains of Unknown Function" (DUFs) or "Uncharacterized Protein Families" (UPFs) in Pfam database have been analyzed for both structure and function by computational structural genomics approach (Betman et al. 2010; Goodacre et al. 2014; Mudgal et al. 2015).
Each of these families contains a group of molecules that resemble one another in both structure and function.
Thus, knowledge representation is a question of both structure and function.
However, analyses of protein structures have repeatedly demonstrated the importance of interactions between amino acids in conferring both structure and function.
Such data provide the first indication of variations in the activation mechanism of these enzymes, which were thought to be comparable in both structure and function.
The field of cognitive aging has associated increased response times and variability with neural dedifferentiation (for example, where both structure and function becomes less focal with age76, 77) which in turn leads to increased neural noise78 (a result also common to children with autism79).
Neither form retains side chain close-packing, and therefore both structure and function must result from other factors, assuming that the reality of the dry molten globule is accepted.
Static models of the epidermis may not do justice to the ECM, which is metabolically active, as it changes both structure and function as it transits to the surface.
We first consider how proposals work rhetorically and persuasively in terms of both structure and function; we then use our analysis to assess some short proposals with an eye to understanding better 1) what makes a proposal compelling and 2) how readers find and use the information they need to become effective advocates.
Interestingly, CRT1 is the orthologoue (a gene homologus in both structure and function) of the human RFX1 protein and displays the same DNA-binding sequence specificity.64 RFX1 interacts with the c-Abl SH3 domain and stimulates c-Abl kinase activity.13 A limited number of RFX1 target genes have so far been identified, and the products of most of them are involved in DNA replication and repair.
Endothelial cells (ECs) from different vascular beds display a remarkable heterogeneity in both structure and function.
