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Both sources of variation complicate prognostic model building, and both may cause biased, inefficient or overly optimistic model predictions.
Despite of higher level of variation associated with array replicates compared to pool construction, we suggest that both sources of variation should be taken into account.
For this purpose, we recorded (in individual-based simulations) the contributions of both sources of variation to the phenotypic mean and variance.
We used logistic regression to test for time trends and regional differences (East vs. West Germany), simultaneously adjusting for both sources of variation.
However, considering the relatively similar levels of variation associated with the array and pool replicates, future studies should incorporate both sources of variation in the experimental design for reliable estimation of allele frequencies from DNA pools.
The objective of this paper is to examine and correct for the influence of both sources of variation, i.e., variation induced by sampling as well as extra variation created by incomplete data.
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Ideally, 95% PIs should take into account both these sources of variation, although we note that parameter uncertainty is usually small compared with the natural variation of the quantities of interest.
Scenario 3 combines both sources of genetic variation, direct additive and paternally inherited variance.
We initially attempted to adjust for both these sources of variation by fitting the same Poisson-lognormal GLMM that was used to simulate the data.
However, since the experimental setup compounds both potential sources of variation, we would expect that any such differences would be maximized in this study.
"Both are important sources of variation between individuals," he said.
More suggestions(15)
both sources of complexity
both sources of production
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both variations of variation
both versions of variation
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both sources of support
both sources of bias
both types of variation
both sources of tension
both sources of error
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