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Nevertheless, both single and repeat dosing with GSK315234 was generally well tolerated.
Following the peak, concentrations declined slowly with a mean terminal t½ of about 300 to 400 hours after both single and repeat dosing.
In addition, the study was designed to provide a basis for evaluating the pharmacokinetic profile and pharmacodynamic effects of both single and repeat doses of idursulfase.
Following both single and repeat inhaled administration of FF 800 μg there were consistently higher Cmax and AUC values in all three East Asian groups with geometric mean ratios for Cmax and AUC ranging from 40%to76%6% greater and 52%to75%5% greater, respectively, compared with the Caucasian group (Table 3).
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This paper is intended to give an overview between ductile and brittle adhesives under both single and repeated impacts.
The comparison of experimental results of the Loctite-9466 applying applying both single and repeated impact energies are shown in Fig. 9.
In order to determine the energy characteristics of the experiments, axial impact loadings were applied as both single and repeated three times under the same conditions.
Meta-analyses have reported that supplementation can result in an approximately 2 to 3%% improvement in a variety of performance measurements (e.g. power, speed, work capacity, time to failure) during both single and repeated bouts of high-intensity exercise [1, 2].
Both single and repeated application of low TNF doses (1-10 micrograms kg-1 i.v).v
Both single and repeated irradiation have been observed to drive EGFR autophosphorylation, with upregulated EGFR expression also reported.
Both single and repeated nalmefene oral dosing led to a very high μ-OR occupancy and 50 h after administration, the occupancy was still ∼50% while plasma concentrations were negligible.
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