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Therefore possibly both side chains and molecular weight contributed to the difference in the absorption spectra in solid films.
The polar groups are apparently distributed at irregular intervals in both side chains and along main chains; hence, the structural design is not of regular geometric pattern.
This may be due to the stacking of the aromatic ring of F441 with that of W456, as suggested by the model, which would result in a more compact packing of both side chains, and therefore in a lesser steric impediment of W456 to the binding of the trimethylammonium group of BAL that in the A441I mutant.
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Solid state 19F NMR spectroscopy and fluoride emission measurements demonstrate fluorine loss from both side chain and main chain upon membrane exposure to high temperature and low humidity OCV condition.
The docking calculations suggest that improvement of the ligand affinities could be achieved through optimization of the polar contacts with functional group of T144, R139 and T147 (both side chain and main chain).
Close examination of the bound BiPh(2,3′,4,5′,6 P5 reveals multiple interactions between the 3′-, 4-, 5′-, and 6-phosphates of the ligand and both side chain and backbone atoms of SHIP2.
Multiple alcohols are generated at both side-chain and backbone sites.
Specificity differences can be explained by differences in PDZ residues that are in contact with the peptide ligands, but these contacts involve both side-chain and main-chain interactions.
These studies have led us to conclude that the LexA repressor-protease possesses a unique substrate preference, with both side-chain and conformational requirements that govern autoproteolysis.
Introduced herein is a labelling scheme for H-detected ssNMR, and it gives high quality spectra for both side-chain and backbone protons, and allows quantitative assignments and aids in probing interresidual contacts.
As the hydroxy groups exist in both side chains of serine and threonine, and both amino acids also occupy similar spaces in the side chains, the explanation for Ser to have such an impact in chloride-dependent λmax changes of HwHR requires further study.
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