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Surprisingly, the electron donor substituted 7d and 7e and the nitro substituted derivative 7 g registered a similar intensity close to that given by the parent fluorophore 2. A comparative UV absorption graph for both series of compounds is shown in Figure 1. Figure 1 UV-Visible absorption spectra of imidazo[1,2-a]azines 6 and 7. Figure 2 shows a comparison of the emission intensities.
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Biological data on both altinicline and the series of compounds from which it was selected are reported.
Therefore, it was suggested that this series of compounds can bind to both rodent and human GlyT1.
Bill and his Strathclyde team did most of the preclinical pharmacology on a new series of compounds, including vecuronium and rocuronium, both in common use by anaesthetists worldwide.
To demonstrate DESPS using the newly designed encoding language, we prepared a series of compounds that exhibit diversity in both scaffold configuration and isomerism.
The obtained series of compounds exhibits low affinity and activity both at opioid receptors and as cyclooxygenase (COX) inhibitors.
Based on the newly identified hit compound 17a, three series of compounds were synthesized and evaluated for both HDAC1 inhibitory activity and cytotoxicity.
These series of compounds were also found to be active against both L. infantum and L. tropica.
We had previously synthesized a series of compounds based on endogenous cannabinoid ligands that targeted both CB receptors and T-type calcium channels.
We prepared a series of compounds that include candidates showing activity against the targets of both trimethoprim; dihydrofolate reductase, and ciprofloxacin; DNA gyrase and topoisomerase IV.
"We thought the expected negative pharmacological results would cap our work on this series of compounds," one of his colleagues later recounted.
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CEO of Professional Science Editing for Scientists @ prosciediting.com