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The mechanism behind off-target enrichment is highly complex and contingent on both sequence properties and stochastic processes.
We want to point out that both sequence properties and GO annotations are important for the correct identification of candidate genes for cancer.
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The same analysis was performed for the median length of the 3' UTR sequences on each chromosome, and z-scores and p-values were estimated for both sequence properties.
We recently reported classification of curated RET gene variants using primary amino acid sequence properties and Naïve Bayes [24].
The main goal of the present work was to gain insight into sequence properties and distribution of FRT-like sequences in the human genome.
For genome engineering experiments to be successful, one needs data on sequence properties and distribution of target-like sites within the genome of interest.
D-Tailor provides an integrated Python-scripting framework for multidimensional analysis of sequence properties and for the design of artificial sequences constrained by multiple sequence properties of interest.
We analyze the above protein sequence properties and summarize the results in Table 6.
In this paper we will characterize the properties of A-to-I editing sites in terms of their secondary structure properties, their sequence properties, and their thermodynamic properties.
Clearly, such underlying complexities in SP functionality, will weaken correlations between SP sequence properties and secretion levels.
By jointly considering sequence properties of microsatellites in the human RefSeq sequence together with properties of genetic diversity in human populations, we have produced the first genome-wide systematic analysis of the relationship between diverse microsatellite sequence properties and features of human microsatellite variability.
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