Sentence examples for both sequence and structure from inspiring English sources
The reentrant loops are similar in both sequence and structure (Supplementary Fig. 2b, c).
Simple exact models (SEMs) are well-positioned to address general principles of evolution as they permit the exhaustive enumeration of both sequence and structure (conformational) spaces.
The yeast prion Ure2p is composed of an N-terminal prion domain, and a C-terminal globular domain, which shows similarity to glutathione transferases (GSTs) in both sequence and structure.
In this study, we propose a novel method for predicting protein-RNA interactions based on both sequence and structure descriptors of protein and RNA (e.g., the sequence-based physicochemical features, the secondary and three-dimensional structure-based features).
By using both sequence and structure databases and by exploiting the latest techniques in machine learning it is possible to routinely predict protein secondary structure with an accuracy well above 80%.
Bacterial and mammalian channels differ significantly in both sequence and structure.
Although these protocols did show better performance than the nearest neighbor homology-based procedure used as bench mark above, they never achieved accuracies higher than 75%, which is significantly less than what was achieved by using both sequence-and structure-based features.
Analysis of the interaction of the diphenylfurans with RRE and TAR RNA model systems by gel shift assays indicates that they exhibit both sequence and structure-dependent binding modes.
Surprisingly, on the Petrova dataset, INTREPID is as accurate as their support vector machine (SVM -based method, even though the latter uSVM -basedequence and structure-based features.
Three are sequence-based (SIFT [ 18], LRT [ 5], and MutationAssessor [ 19]), while two are both sequence and structure-based (PolyPhen2_HumDiv and PolyPhen2_HumVar [ 20]), and the sixth is the MutationTaster Bayesian classifier [ 21]).
