Sentence examples for both sequence and structural from inspiring English sources
Five among the six loops (L1, L2, L3, H1, H2) adopt only few canonical structures, while the H3 loop is the most variable in both sequence and structural conformation (Al-Lazikani et al., 1997; Morea et al., 1998).
Divergence in function of homologous proteins is based on both sequence and structural changes.
We experimentally validate two aptamers whose binding required both sequence and structural features.
We note that viruses belonging to 20 different families fall into only five distinct structural groups, suggesting that optimal virus classification approach should equally rely on both sequence and structural information.
Indeed, even in those cases where these data exist (for both, sequence and structural patterns), they usually refer to the orthosteric site, but do not consider allosteric sites which have been shown to be fundamental for protein function and drug design [10, 38].
The computational method employs an effective scoring function which translates both sequence and structural information of HA into quantitative HA-receptor binding strength by evaluating the effects of electrostatic and shape complementarity.
In this report, assignment of functional domains was carried out by a very sensitive method HHpred [ 30], which uses both sequence and secondary structural information in HMM-HMM comparison method.
In step 7, statistical analyses both on the sequence and structural levels were then performed to map out the antigenically important regions of the HA protein, by summarizing the frequency of each amino acid residue appearing in the antigenic peptides (see also Fig. 4).
The PS1-hp beta-finger structure is conserved in both Mcm4 and Mcm5 proteins of yeast by both primary sequence and structural alignment.
56 positive clones with a RAYS ratio ≥2 were considered as antigenic and analyzed at both the sequence and structural level [26].
The presence of distant internal repeats in length-deviant superfamilies has been carried out using computer algorithms, both using sequence and structural information.
