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CMfinder and RNAPromo discover motifs (SCFG-based stochastic models) which are both sequence and secondary structure based.
Although totally unrelated in both sequence and secondary structure, the Rpf and Sps domains fulfil the same function.
We discuss representatives of 23 types of ncRNAs that were detected based on both sequence and secondary structure homology.
Clearly, two duplexes are conserved in both sequence and secondary structure across 71 land plant species from moss to flowering plants.
To identify functional domains in protein sequences, we used a sensitive HMM-HMM comparison method, HHpred [ 30, 55], which employs both sequence and secondary structure information to identify remote homologs.
(PS) (http://140.113.239.111/~ps2v2/docs.php) is an automatic homology modeling server that combines both sequence and secondary structure information to detect the homologous proteins with remote similarity and target-template alignment [ 96, 97].
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In addition, the 3′UTR of MECP2 is highly conserved in both sequence and RNA secondary structure (Coy et al., 1999).
We aligned the MIR159/319 stem-loops considering both sequence and RNA secondary structure by a semi-automated strategy (see Methods).
Here we are concerned with alignment of structural RNAs, using models that consider both primary sequence and secondary structure constraints.
In the process of identifying and analyzing numerous SRP RNAs in protozoa and fungi we have demonstrated that the RNA portion of the Alu domain is highly variable both in sequence and secondary structure.
However, in the case of the extra trnP and trnQ tRNAs of A. aspersa, these extra genes appear to strongly differ from their homologs in both sequence and length of their secondary structure elements.
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CEO of Professional Science Editing for Scientists @ prosciediting.com