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In summary, both sequence and length of the inter-domain linker determine ZFN activity and target-site specificity, and are therefore important parameters to account for when designing ZFNs for genome editing.
The rice telomere has diversity in both sequence and length.
Each of the more widely shared elements appears degenerate, varying extensively among species in both sequence and length (Table S2; Figure 3).
The C-terminal region is more divergent with respect to both sequence and length variation.
Precursor peptides vary in both sequence and length, and therefore, it is likely that many precursor peptides remained unidentified using this stringent method.
However, in the case of the extra trnP and trnQ tRNAs of A. aspersa, these extra genes appear to strongly differ from their homologs in both sequence and length of their secondary structure elements.
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According to the data available at the GeneDB database [ 14], the locus is located at chromosome 13 and contains twelve copies (LmjF.13.0280 to LmjF.13.0390) having identical ORFs both in sequence and length (1356 bp), arranged in a head-to-tail tandem organization.
Although poly-Q containing proteins are generally more highly conserved in mammals, paradoxically their repeat regions are typically poorly conserved both in sequence and length, and they have been implicated in the rapid functional diversification of these proteins and the continuous morphological evolution of mammals [ 13- 15].
The lack of a unique best match, in terms of both sequence identity and length of alignment, was recorded as absence of that particular family member in the Salinas genome.
There are major differences in the cytoplasmic domains of Sn of different species, both in amino acid sequence and length.
Although having sequence and length variations, both ZiPD- and ELAC2-type flexible arms comprise a GP motif rich in glycine and proline residues [ 35], followed by a Walker A-like motif [ 9].
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