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All entries are thoroughly annotated with both sequence and functional information.
We have complemented this analysis, on a smaller dataset, by adding additional information relating to a single copy nuclear gene, where orthology has been inferred by both sequence and functional characterisation.
Similar(58)
Immediately after a duplication event the pair of freshly duplicated genes is thought to be identical in both sequences and functional roles in the cell.
We align the networks using both sequence and our functional similarity measures.
NH1 is both the sequence and functional ortholog of Arabidopsis NPR1, which is a key regulator of SA-dependent systemic acquired resistance [36] and functions downstream of OsMPK6 in bacterial blight resistance [37].
Thus, the loss of the original function of LexA in Synechocystis sp. PCC6803 is coupled with the loss of the sequence constraint, thereby accelerating its divergence from other cyanobacterial LexA proteins, at both the sequence and functional levels.
These results indicate that most of these human and mouse regulatory regions have been under selective pressure both at the sequence and functional level.
Of these, 100 of the intergenic predictions and 800 of the 3' and 5' UTR predictions show very high conservation of both sequence and structure, indicating likely functional relevance.
Both of these DUBs share sequence and functional similarities and are ubiquitinated by the pVHL E3 ligase complex and targeted for degradation (Li et al. 2002 b ).
Sequence and functional analysis indicate that both human and mouse express a number of neutrophil-activating chemokines.
The protein sequence and functional information of DEGs were obtained from UniProt database73 or InterProScan tool for functional domain identification74.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com