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We used the most accurate mode that uses both sequence and evolutionary profiles.
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The method is conceptually straightforward, and is based on an information-theoretic model that accounts for both sequencing error and evolutionary divergence, providing the means to encode the set of sequencing traces.
Our domain definitions are based on structural, functional, sequence and evolutionary considerations after careful study of relevant literature and inspection of domains defined by existing automated methods.
SOK performed the sequence and evolutionary analyses.
WG performed sequence and evolutionary analyses.
JK, ASM and SOK performed the sequence and evolutionary analyses.
BQG and JSJ performed sequence and evolutionary analyses, and wrote the gene family finder code.
Its DNA sequence and evolutionary origin are different from other point centromeres.
Our study showed that cancer genes have distinctive functional, sequence and evolutionary characteristics from COSMIC, OMIM and non-cancer genes.
Sequence and evolutionary analyses reveal significant differences in the evolutionary signatures of Rhox 2,3 and 4 paralogues indicative of distinct selection pressures.
Parameters such as the number of sequences and evolutionary distance between sequences were considered during alignment.
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