Characteristics of this concept in terms of spatial resolution and dopant gradient resolution as well as in terms of concentration sensitivity and quantification procedures are briefly presented.
By using well-designed magnetic nanocomposites (MNCs) as probes, immunochromatographic test strip (ICTS) has shown some advantages in sensitivity and quantification of in vitro detection methods.
Scanning spreading resistance microscopy (SSRM) has evolved as one of the most viable approaches over the last decade due to its excellent spatial resolution, sensitivity and quantification accuracy.
However, progress is continuously being made in research laboratories pushing the limits of the approach to consistently improve its performance in terms of spatial resolution, sensitivity and quantification.
A greater control of the cellular microenvironment not only improves the control of experimental design and reproducibility but also facilitates the exploration of methods to enhance the sensitivity and quantification of proteins and their modifications.
Future work to construct a handheld, mobile-linked device can leverage this technology to improve sensitivity and quantification of antigen levels for any gold nanoparticle based LFA.
Tomographic approaches such as Diffuse Optical Tomography (DOT) [ 5– 8] and Fluorescence Molecular Tomography (FMT) increase the capabilities of optical imaging and offer many advantages including cost reduction, ease-of-use, molecular specificity, sensitivity and quantification accuracy [ 9– 11].
Recent advances in mass spectrometry technologies have improved the sensitivity and quantification reliability of LTQ, Orbitrap and TOF, so that new generations of these MS instruments can also quantify attomole levels of proteins in SRM/MRM mode.
PEG 5 -BP-USPIOs can also be labeled using a radiolabeled BPEG 5 -BP-USPIOs, that allows tracking of the NPEG 5 -BP-USPIOsmaging with high sensitivity and quantificanion calsoilities.
Recently, JCPyV and BKPyV IgG have been explored as risk predictors in multiple sclerosis and transplant patients, but sensitivity, specificity and quantification issues limit current performance.
