MCL cell lines expressed VD3 receptor (VDR) and VDR expression was further increased by VD3 in both sensitive and resistant MCL cell lines, indicating that resistance to VD3 was not related to the lack of VDR expression (Supplementary Figures S1B and C).
The S6 and 4E-BP1 findings were interpreted as indicating that mTOR signaling was sensitive to rapamycin in both sensitive and resistant cells and that the sensitivity of cells could not be accounted for by the ability of rapamycin to induce dephosphorylation of these mTOR targets.
Although HIF-2α plays an important role in regulating the level of DR5, renal cancer cells containing this protein are both sensitive and resistant to TRAIL-induced apoptosis, suggesting that sensitivity to TRAIL is controlled by a complex set of proteins other than the receptor.
The lead compounds in the set, dinitro derivatives exhibited significant activity against both sensitive and resistant strains of M. tuberculosis and also against non-tuberculous mycobacteria.
In addition, SSB/PLK1 siRNA encapsulated in HA-PEI/PEG nanosystems demonstrated dose dependent and target specific gene knockdown in both sensitive and resistant A549 lung cancer cells overexpressing CD44 receptors.
The different compounds inducing a high efflux of GSH were evaluated on both sensitive and resistant cell lines, and two of them, belonging to the flavones class were found to be more cytotoxic on resistant cancer cells, with the best selectivity ratio >9.1.
Interestingly, compound 1 was active on both sensitive and resistant cell lines.
C60-mediated photodynamic effect was demonstrated also on leukemic L1210 cells both sensitive and resistant to cisplatin.
