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Although it may seem paradoxical, relearning methods can yield both sensitive and insensitive measures of forgetting.
Concerning to other leukemias and lymphomas, all disease types contained both sensitive and insensitive cell lines.
At the protein modification level, IFN- γ stimulated phosphorylation of Y701 residues in both sensitive and insensitive cells consistent with previous studies that demonstrated lack or weak correlation between Y701 STAT 1 phosphorylation and cell sensitivity to cytokine stimuli (Chawla-Sarkar et al, 2002; Kortylewski et al, 2004).
The WERF EPHect SOPs recommend using precooled transport/fixation media (where applicable) and keeping samples on ice (4°C) at all times before storage to allow utility of the samples in assays that are both sensitive and insensitive to room temperature conditions.
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Furthermore, identification of the phosphatase(s) activity that is involved may provide a useful biomarker that could distinguish PI3K/Akt/mTORC1-inhibitor sensitive and-insensitive cancers and whether a combined inhibition of both pathways could be beneficial to the patients.
These results suggest that although the G1 and S phases of the cell cycle are responding similarly to changes in O2 concentration in both O2 sensitive and insensitive cell lines, it is the G2 phase of the cell cycle that is not responsive to O2 concentration in the O2 insensitive cell lines.
BSO treatment increased apoptosis induction both in sensitive and insensitive cells.
Furthermore, there are three amino acids containing hydroxyl group, S, T and Y, all of which have codons in both the sensitive and insensitive categories.
Advanced GEM models with multiple genetic abnormalities, able to generate both hormone sensitive and insensitive tumours and in which metastasis occurs at clinically relevant sites will also be a desirable refinement [ 376, 377].
Cancer cell lines grown in the presence of NA that remained sensitive to STF-31 invariably had low expression of NAPRT1, relative to both insensitive cells grown with NA and other cancer cell lines (both STF-31 sensitive and insensitive) grown in media not containing NA, supporting the role of NAPRT1 in nicotinic acid-mediated rescue of STF-31 cytotoxicity.
Results were compared between treatment conditions to define commonly altered genes in both PARP inhibitor sensitive and insensitive cell lines.
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